Mark Gurarie is a freelance writer, editor, and adjunct lecturer of writing composition at George Washington University.

Hydroquinone is a topical treatment for conditions that discolor the skin, such as melasma, eczema, age spots, and acne scars. Available over-the-counter as well as in prescription-strength formulations, this cream or gel works to lighten and fade away darker spots and patches on the skin.

Used since the 1960s, there has been controversy about the safety of hydroquinone. Because of links to malignancy and toxicity at high doses in animals, the U.S. Food and Drug Administration (FDA) even proposed a ban on the product in 2006. In light of additional research, the call was withdrawn, and it remains available in the US.

This article provides a quick look at how hydroquinone works and the skin condition it treats. It also discusses how to use it safely, potential side-effects, and potential alternatives.

Hydroquinone treatment lightens the skin gradually and has a reversible effect. It does so by interfering with the production of melanin, the black or brown substance responsible for the pigmentation of the skin, eyes, and hair. Acting on melanin-producing cells, or melanocytes, hydroquinone prevents the conversion of the amino-acid, dihydroxyphenylalanine (DOPA) to melanin by affecting the activity of its precursor, tyrosine.        

Applied over time, hydroquinone has a two-fold effect. Not only is the production of melanin interrupted, it interferes with the reproduction of melanocytes, reducing their number. This leads to the desired, lightening effect on treated areas.     

A wide range of dermatological conditions cause darker spots, patches, and blemishes on the skin, clinically referred to as hyperpigmentation . With regular application, hydroquinone lightens the skin to correct this set of issues. Here’s a quick breakdown of the conditions that can benefit from this treatment.

The formation of brown, tan, bluish or gray patches or freckles on the face is the hallmark of melasma, also known as chloasma or “ pregnancy mask.” The discoloration typically affects areas of the face that get regular sun exposure. This nonlife-threatening condition is triggered by hormonal changes or as a side-effect of certain medications.

Most commonly seen in younger women with brown or light brown skin, though anyone an develop it, melasma is most often caused by:

In some cases, melasma patches and spots go away on their own. For instance, pregnant women may see them fade after delivery.

Also known as dermatitis , eczema refers to a set of inflammatory responses in the skin. This causes scaly, dry, and itchy skin, as well as rashes on the face, elbows, knees, and on the hands and feet. Eczema is especially problematic because scratching affected areas can lead to bleeding or infection.

The exact causes of this noncontagious skin disorder are unknown, though evidence suggests it’s likely caused by a combination of genetic and environmental factors. Eczema is most common in infants or children, and in some cases, it fades with age. However, it can affect adults, too, and is typically a long-lasting or chronic condition.

When the pores of the skin become clogged with oil or dead skin particles, acne arises, characterized by bumps and spots on the face and body. These may range from blackheads, red spots, known as pimples, and whiteheads, in which the affected pore is pus-filled. Commonly arising in adolescence, 80% of teenagers experience acne, though people of all ages can be affected.

As the affected skin heals, a thicker substance called collagen develops, which can cause permanent scarring and discoloration of the skin. Several types of scarring occur, including:

You’re more prone to develop acne scars when the acne is more severe, you pick or pop whiteheads or blackheads, the condition is longstanding, and you have a family history of them.

Psoriasis is a chronic autoimmune condition that affects the skin by speeding up the lifecycle of cells. It’s typical signs are patches of thickened, red skin and the appearance of silvery scales. This discoloration often affects the face and is also seen in the scalp, knees, elbows, lower back, palms, and soles of the feet.   

Between 10 and 20% of people with psoriasis develop psoriatic arthritis. Like other types of arthritis, this condition causes painful inflammation in the joints. When arising alongside psoriasis symptoms, you’re considered to have psoriatic disease, which prompts treatment.  

Also known as liver spots, age spots are brown and black spots on skin that’s often exposed to the sun. They typically arise as a natural result of aging or due to cellular damage caused by sunlight or ultraviolet (UV) rays. Unrelated to any other disease, age spots are painless. They can, however, resemble other, more serious skin conditions.   

While the skin conditions hydroquinone treats aren’t themselves serious, they can resemble symptoms of more serious health conditions. If you’re concerned, be sure to seek out a diagnosis from a dermatologist or your health provider.

Broadly speaking, hydroquinone creams and gels are well-tolerated and safe to use for all skin types. Despite reports of toxicity in animal studies, when performed under a dermatologist’s supervision, the risk of side-effects or negative effects is minimal. Most complications arise with unsupervised, over-the-counter use.

This treatment may not be effective in every case. Discomfort can worsen when applied to sensitive or very dry skin may be prone to additional irritation when using hydroquinone. Prolonged use may also cause the discoloration to worsen if you have darker skin.

As noted, hydroquinone creams or gels come in over-the-counter 2% and prescription-strength 4% solutions, such as Tri-Luma. Generally, it’s advised to test the solution on a smaller area first to see if there’s irritation or any side-effects before full application.  

Here’s a quick rundown of how to apply hydroquinone:

Critical for successful treatment is protection from the sun. You’ll need to wear strong sunscreen every day, hats, and work to avoid direct sunlight. Exposure further damages the skin and can prompt hyperpigmentation to return.  

The effect of hydroquinone on skin pigmentation is reversible. If you stop, the melanocytes affected by treatment start to resume normal activity, causing the blemishes or spots to gradually reappear.

Since long-term use can increase the risk of side-effects, dermatologists recommend daily application for three to six months, followed by rest periods of less frequent, maintenance use. These maintenance periods—in which hydroquinone is only applied two to three days a week—have been shown to preserve the results of treatment up to six months after stopping.  

Contrary to the concerns raised by the FDA, hydroquinone has been consistently shown safe, especially when used under physician supervision. That said, side-effects can arise with this treatment. These may include:

Long-term use, especially when it’s unsupervised, can lead to ochronosis. This is characterized by patches of diffuse bluish or black pigmentation on the skin, broken up with lighter, curved deposits.

While hydroquinone has cemented its place in the treatment of hyperpigmentation, it isn’t the only approach to lightening skin. Even though it isn’t dangerous, some may balk at the idea of applying a chemical daily or find treatment ineffective. As laid out below, there are several natural alternatives to hydroquinone.   

Present in a range of beauty products and foods, antioxidants, especially vitamins A and C, may also help treat hyperpigmentation on the face. Researchers have found vitamin C, also known as ascorbic acid, to inhibit the production of melanin and is effective against blemishes and spots.

Vitamin A, and compounds of its family, retinoids, can also treat spots and blemishes. Topical creams with this antioxidant are considered a viable alternative to hydroquinone for skin lightening.    

Plants also produce antioxidants and acids that can help with hyperpigmentation. Often found in cosmetic solutions and creams, a range of naturally-derived, botanical extracts and agents may help, including:

Also known as niacinamide or just niacin, vitamin B3 is also known to treat hyperpigmentation. It’s an ingredient in a number of combined formulas for skin lightening. Known to smooth wrinkles and lines, this vitamin helps suppress the activity of tyrosinase, thereby limiting melanin production.

Hydroquinone is a topical agent used to treat discoloration on the skin due to age spots and acne scars, as well as dermatological conditions like melasma and eczema. Available as a cream or gel, it’s available both over-the-counter or with a prescription. Over time, the use of hydroquinone causes blemishes to fade, though prolonged use can cause side-effects. Though there have been concerns about safety, used properly, it’s been found to be well-tolerated and effective.

While the skin conditions hydroquinone treats aren’t dangerous, blemishes, patches of discoloration, and other issues can significantly impact self-esteem and quality-of-life. Nowadays, there’s a lot you can do to correct these issues and restore your self-confidence. If you're unsatisfied with how your skin looks–or aren’t sure what’s on your skin–it’s worth reaching out to a dermatologist and exploring your options.

There are several approaches to getting rid of dark spots or blemishes on your face. Among the primary options are:

While hydroquinone is unsafe to eat and can hurt your eyes, it’s designed for use on the face. Despite some concerns about its toxicity in animals, this treatment has been found to be safe and well-tolerated. With long-term use, especially if it’s unsupervised, there is a risk of side effects, such as itching, redness, or inflammation. In rare cases, long-term use leads to ochronosis, characterized by patches of blue or gray, speckled skin on the face.

Hydroquinone works by suppressing the production of melanin, the brown substance that regulates skin pigmentation. Over time, blemishes, scars, or other colored areas fad. However, the effect is reversible; stopping treatment and exposure to sunlight can reverse the condition. Since too much hydroquinone can cause side-effects, dermatologists typically prescribe daily treatments for three to six months, followed by periods in which less frequent dosing is needed.  

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By Mark Gurarie Mark Gurarie is a freelance writer, editor, and adjunct lecturer of writing composition at George Washington University.  

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